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In contrast to erastin, RSL3 activates a similar death mechanism, but in a mitochondrial VDAC (voltage-dependent anion channel)-independent manner
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Outcomes: Incidence of 13 obesity-related cancers (bladder, colorectal, kidney, breast, endometrial, thyroid, pancreatic, meningioma, liver, upper gastrointestinal, ovarian, multiple myeloma, and prostate) and lung cancer
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