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Discovery of a potent, selective, and orally bioavailable c-met inhibitor: 1-(2-Hydroxy-2-methylpropyl)-N-(5-(7-methoxyquinolin-4-yloxy)pyridin-2-yl)-5-methyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazole-4-carboxamide (AMG 458)

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Zhu M, Zhang QJ, Wang L, Li H, Liu ZP

While human clinical trials remain limited, the depth of animal research, consistency of positive findings across multiple study designs, and extensive community experience create a reasonable basis for therapeutic use

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