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Somatostatin, secreted from pancreatic -cells, acts as an inhibitory paracrine to suppress glucagon release from pancreatic -cells, and specific blockade of SSRT2 eliminates the inhibitory effect of GLP-1 on glucagon secretion

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Then, the cells were washed with PBS and lysed with PTTS buffer (0.5% Triton-100, 0.1% Tween-20, and 0.05% SDS) containing a protease inhibitor (Cat

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FDA-approved since 2005, GLP-1 agonists, including exenatide and newer formulations, have shown promise in improving glycemic control and aiding in sustained weight management (7)