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By reaching the BBB via olfactory pathways, IN chelators like DFO achieve CNS exposure faster and better than systemic routes, yet without the need for surgery or injections

The escalation schedule is designed to reduce side effects

Emerging opportunities include expanding indications beyond diabetes and obesity into cardiovascular risk reduction and exploring combination regimens to optimize outcomes

Finally, convenient once-daily oral dosing may promote patient adherence and improve health outcomes

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District Judge Richard Gergel, overseeing thousands of these lawsuits, had granted preliminary approval for the two settlements in August