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Di Geronimo G., Caccese A

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These symptoms reflect both the medication's action and the body's adjustment to a sudden deficit in energy intake

This study is a meta-analysis of previously published randomized controlled trials and does not involve new data collection from human participants

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Based on the review, the researchers reported the following findings: Patients who received weekly 50 mg oral semaglutide reported a higher incidence of altered skin sensations, such as dysesthesia (1.8% versus 0%), hyperesthesia (1.2% versus 0%), skin pain (2.4% versus 0%), paresthesia (2.7% versus 0%), and sensitive skin (2.7% versus 0%), than those receiving placebo or comparator