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These nerves release norepinephrine (NE), which activates 1-ARs broadly expressed on hepatocytes and hepatic sinusoidal endothelial cells, regulating gluconeogenesis, glycogenolysis, and lipid metabolism 17,18,19,20,21

Subcutaneous injection into abdominal fat or near the site of injury (as commonly practiced by self-experimenters) is the most reported approach, but this is not a clinical protocol

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