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A 2025 meta-analysis published in Endocrinology, Diabetes & Metabolism, pooling data from four studies with nearly 29,000 patients, confirmed a consistent advantage for tirzepatide, with an average additional weight reduction of 4.84 kg compared to semaglutide

Protein: Many people aim for around 1.5-2.0 g/kg/day to support satiety and preserve lean mass

Two novel missense mutations of the OCTN2 gene (W283R and V446F) in a patient with primary systemic carnitine deficiency

Significant fatigue or energy crashes that do not resolve by mid-week

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