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Some institutions may use supraphysiologic replacement up to 20 mg of hydrocortisone two to three times daily with a 2- to 4-week taper

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Notably, shorter treatments with smaller doses of RSV, like 300 mg daily for three months, manifested beneficial results, including reduced ALT and AST levels, better lipid metabolism, and diminished inflammation [175], yet the prolonged usage of higher doses in some studies did not reflect such benefits [176]

If youve been taking high doses of melatonin, you may experience rebound insomnia, where your sleep gets worse when you stop taking the supplement