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Maintaining weight loss after GLP1 treatment requires more than medication alone

Oral semaglutide may even lead to less nausea and vomiting than once-weekly dulaglutide and once-daily lixisenatide (two less common GLP-1 injectable medications), though its nausea profile is similar to that of injectable semaglutide

Patients can expect the following benefits: Decreased appetite Improved blood sugar control Increased fat loss Reduced risk of specific health conditions, such as hypertension and elevated cholesterol levels

But what that kind of profile says is that its better to be overweight and strong than it is to be normal weight and weak or unfit

It is also, per recent mechanistic work, responsible for PCSK9 degradation, which is the likely pathway behind the LDL cholesterol reductions seen in TRIUMPH-4

This raises the question of whether some patients might require longer treatment to sustain weight loss