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The transcriptional levels of five key genes ( hmgR, ipi, carG, carRA, carB ) and SR5AL obtained by qRT-PCR were normalized to that of the tef1 gene

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How HRT Works Hormone replacement therapy (also known as Menopause Hormone Therapy MHT) involves the use of estradiol (estrogen) with or without progesterone, and it directly addresses the hormonal root cause of menopausal metabolic changes: Reduces visceral fat accumulation: Research from the OsteoLaus cohort found that current HRT users had significantly lower visceral adipose tissue, BMI, and abdominal fat mass compared to never-users [7]

But just to get the audience on the same page because the way we could define the evidence being far along or not far along may differ