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In the validation stage, an independent cohort (Cohort 2) comprising four age- and sex-matched groups (30 RBD-PD patients, 14 non-RBD-PD patients, 30 iRBD patients and 30 Ctrl subjects, all of whom underwent gold-standard video polysomnography (vPSG) assessment for the confirmation of RBD status) was included

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1 Introduction Acute kidney injury (AKI) represents a critical medical condition linked to rising morbidity and mortality rates, affecting 10%15% of hospitalized individuals, with up to 50% of those requiring admission to intensive care units (Ronco et al., 2019