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Pickart and colleagues reported in Nature (1980) that the tripeptide facilitates copper uptake into cultured cells, and potentiometric titration places the GHK-Cu stability constant at log K of approximately 16.4, marginally above the copper transport site of human serum albumin at roughly 16.2

View Study [5]"Stem cell recovering effect of copper-free GHK in skin" Choi HR, Kang YA, Ryoo SJ, Shin JW, et al., 2012 Finding: GHK increased the number of stem cells in skin tissue and boosted their ability to multiply

The limitation of this study is that it only tested one dose and did not compare it with positive controls given anti-depressants

Chronic cadmium exposure induces hepatic dysfunction and gut microbiota dysbiosis in mice

doi: 10.1038/s41514-023-00124-2

Theoretical concerns exist with anticoagulants, blood pressure medications, and immunosuppressants