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Richter showed that addition of GLP-1 caused increase in 35S-sulfate-labeled macromolecule secretion and relaxation of the pulmonary artery [111]

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The two cohorts of healthy subjects to receive 40 and 60 mg were combined and the cohort of subjects with T2D to receive 60 mg was adjusted to 40 mg, thus resulting in three cohorts: healthy oral semaglutide 20 and 40 mg, and T2D 40 mg