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For instance, an EDS patient whose pain is relieved by a series of prolotherapy injections might find that in a year or two, symptoms slowly creep back if the mechanical stresses continue

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Acta Derm Venereol 96(6):732736

c , Compartment of IC50 between A01, A17, SMART1Et and SMART1 (72 h) in HCT116 cells (n = 4 independent experiments)

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While some early-phase human studies have shown preliminary results, robust evidence from large randomised controlled trials is still pending