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Diabetes Care, 46(Supplement_1), S1S322

Utilization patterns of glucagon-like peptide-1 receptor agonists in patients with type 2 diabetes mellitus in Germany: a retrospective cohort study

ResultsGut hormones and food intake During and after meal, ingested nutrients alter the release of gut peptides that may potentially modulate the food intake and contribute to a three-steps process: meal initiation, within-meal satiety and across-meal satiety influences.4 Meal initiationGhrelin Originally isolated as the endogenous ligand for the growth hormone secretagogue receptor (GHS-R) and for its capacity to stimulate growth hormone (GH) secretion, ghrelin is also the only orexigenic signal from the gastrointestinal tract and a long-term regulator of energy homeostasis.5 This 28 amino acid peptide is modified post-translationally with an eight-carbon fatty acid by the enzyme ghrelin-O-acyl-transferase (GOAT)

Visceral fat leeches fatty acids called adipokines or chemokines, which cause systemic inflammation in the body

We start with the dominant symptom, monitor response, and add therapies in a staged fashion, always weighing metabolic and oncologic risks

doi: 10.1007/s00125-005-0126-y 199 LincoffAMBrown-FrandsenKColhounHMDeanfieldJEmersonSSEsbjergSet al