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A comprehensive review of recent clinical data highlights that while folate deficiency is common among individuals with ASD, maternal folic acid supplementation does not correlate with higher risk of the disorder, indeed folate therapy has been associated with improved neurodevelopmental outcomes (Vasconcelos et al., 2025)

doi: 10.1056/NEJMp2300938 292

This objective data helps clinicians distinguish between true polyuria (excessive urine production) and urinary frequency with normal total volume, guiding appropriate investigation

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