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The review confirmed that NNMT-mediated NAD+ depletion impairs mitochondrial function, SIRT activity (particularly SIRT1 and SIRT3), redox balance, and energy metabolism, creating conditions relevant to cardiovascular disease research models

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Diabetes 63 , 934946 (2014)

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Experimental investigations have examined the relationship between NNMT inhibition and regulatory pathways involving nicotinamide turnover, methylation dynamics, transcriptional control mechanisms, and downstream signal transduction processes

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