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We obtained 48,990 3,644 (mean s.e.m.) reads of operational taxonomic units (OTUs) in SPF group samples, 39,887 3427 (mean s.e.m.) reads in Amp-treated samples, 51,431 4405 (mean s.e.m.) reads in Neo-treated samples, 54,438 1620 (mean s.e.m.) read in Metro-treated samples, 44,004 2154 (mean s.e.m.) reads in Vanco-treated samples

Dose-dependent exposure was also observed in the MAD portion, with steady-state achieved in 0.75 and 1.5 mg/day subjects on day 29 (57)