NNMT depletes the NAD+ precursor pool by methylating nicotinamide the same nicotinamide that the salvage pathway would otherwise convert back into NAD+ via the enzyme NAMPT
Maybe it really did help those people, or maybe it was something else they did (like eat healthier, stop drinking, etc.), but without well designed studies we dont know if its true for sure
By using a ready-to-use strip, researchers can reduce preparation-related variability while maintaining experimental control throughout extended study timelines
Consistency and duration matter more than escalation
Transparency about your medication timeline is critical in these situations
the 2.4 mg dose produced 16.9%, only 3.7% more despite more than doubling the dose and significantly increasing GI side effects (Wilding et al., NEJM 2021)