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Loscalzo, Joseph [Journal of Pharmacology and Experimental Therapeutics, 1998, vol

Its most-discussed proposed mechanism is telomerase activation the enzyme that maintains telomeres at the ends of chromosomes

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When their seminal research was published in *Cell* in March 2017, it introduced the first precision senolytic peptide capable of selectively eliminating senescent cells while sparing healthy tissue, opening unprecedented opportunities for studying aging mechanisms and developing research tools for age-related cellular dysfunction