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Gmez V, Eykyn TR, Mustapha R, Flores-Borja F, Male V, Barber PR, Patsialou A, Green R, Panagaki F, Li CW, et al

Red flags requiring immediate evaluation include severe abdominal pain (possible pancreatitis), persistent vomiting leading to dehydration, suicidal thoughts, development of new eating disorder behaviors, syncope, chest pain, hematemesis/melena, severe constipation/obstipation, orthostatic hypotension, or marked electrolyte abnormalities

"Semaglutide and Cardiovascular Outcomes in Obesity without Diabetes." New England Journal of Medicine

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The difference between those two endpoints, 213 versus 178, could be the difference between still meeting clinical criteria for obesity and reaching a normal BMI range

For the GLP-1 companion programme specifically, the evidence is more recent and still emerging