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Perturbations in the gene regulatory pathways controlling mitochondrial energy production in the failing heart

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A decrease in the expression of the pro-ferroptotic proteins ACSL4, TFR1, and VDAC2/3 and a decrease in dihydroethidium (DHE) fluorescence, iron, malondialdehyde (MDA), and myeloperoxidase (MPO) were further observed in metformin-treated mice

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Its not caused by the drug itself but by rapid fat reduction