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& Gautier, J

SIRT5-mediated SDHA desuccinylation promotes clear cell renal cell carcinoma tumorigenesis

Cancer 27 , 199208 (2020)

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89 Importantly, restoration of hypothalamic autophagy via nutritional interventions such as docosahexaenoic acid-acylated astaxanthin monoester (AST-DHA) supplementation or genetic activation of Atg5 ameliorates obesity and improves glucose metabolism in experimental models, 90 demonstrating that hypothalamic autophagy is not merely correlative but mechanistically regulatory