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Blocking C5aR signaling promotes the anti-tumor efficacy of PD-1/PD-L1 blockade

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The benefits are attributed to N-acetylcysteines mucolytic activity, the ability to restore surface ciliary activity at the nasal epithelium, and modulation of inflammatory response which is central to the immune defence mechanism of nasal mucosa

The advent of therapy that utilizes these pathways as well as the association of bariatric surgery with diabetes remission has (re-)kindled interest in the role of the gastrointestinal tract in glucose homeostasis

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