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To enhance efficacy and reduce complications, combination therapies employ: MAO-B inhibitors (e.g., rasagiline)

The use of reninangiotensin system inhibitors, SGLT-2 inhibitors and novel agents, such as finerenone, have also been shown to slow the progression of DKD to end-stage kidney disease and provide CV protection

Tramadol enhances hepatic insulin sensitivity via enhancing insulin signaling cascade in the cerebral cortex and hypothalamus of 90% pancreatectomized rats

maintenance is essential

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[4] Mayo, K