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This is important because patients who dont lose weight on metformin are considered to be more resistant than others (and therefore more difficult to treat)

How GLP-1 helps insulin sensitivity GLP-1 receptor agonists improve insulin sensitivity rapidly, often before any weight loss occurs

10.1016/j.bbrc.2013.12.109 89

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Analysts note celebrity attention has boosted demand for these drugs, though resulting shortages have led their manufacturer, Novo Nordisk, to scale back some marketing activities

These may include factors such as blood sugar , appetite, insulin, and more