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Pediatric patients require weight-adjusted and usually higher Tac doses compared to adults to reach a certain trough level (97, 98)

Some protocols recommend intramuscular injection into the worked muscle ("site injection"), with the theory that local IGF-1R stimulation drives localized hypertrophy

I think for the sake of time I will not tell my favorite story, which is a story that is both the discovery of rapamycin and perhaps more interestingly the elucidation of how it worked

Wang et al., 2019a)

Initially named Melanotan or Melanotan I, this compound is now referred to by its generic name, afamelanotide