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non-oral or backup contraception is recommended for 4 weeks after each dose increase Pregnancy/lactation: Weight loss therapy is not recommended during pregnancy

Read the full text: Key highlights This narrative review explores mechanisms underlying infertility and PCOS, emphasizing the roles of obesity, insulin resistance, and incretin hormones, along with treatments such as metformin and GLP-1 receptor agonists

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Collectively, these data confirm that weekly subcutaneous retatrutide produces clinically meaningful, dose-dependent weight loss across a range of metabolic populations and study durations