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Small molecule SARM1 inhibitors recapitulate the SARM1 / phenotype and allow recovery of a metastable pool of axons fated to degenerate

Shimaoka, T., Miyake, C

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Furthermore, caveolin 1 knockout augmented steatosis both in vitro and in vivo by enhancing the expression of genes involved in DNL [30], contradicting earlier studies, and suggesting a protective effect of caveolin 1 in NAFLD [30]

To evaluate their genuine leukemogenic potential, researchers engineered a lentiviral CRISPR-Cas9 system that can induce the t(11;19)/MLL-ENL translocation in human CD 34+ HSPCs