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They are naturally occurring in the body, signaling molecules that dictate major physiological processes like tissue repair or metabolism

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Psychological effects of long-term use deserve consideration

Women with polyendocrine metabolic ovarian syndrome (PMOS) [formerly known as polycystic ovary syndrome (PCOS)] [174], a condition frequently associated with adiposity and metabolic disturbances predisposing to diabetes, exhibit reduced ghrelin and LEAP2 levels in relation to the degree of insulin resistance [19, 175, 176]

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doi:10.1097/WNF.0b013e3182a9339dCrossRefGoogle ScholarPubMed Morrow, K, Choi, S, Young, K, Haidar, M, Boduch, C, Bourgeois, JA