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Even clear, colorless solutions may have diminished therapeutic activity, which is why adhering to expiration dates and proper storage conditions is essential for ensuring medication safety and effectiveness

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10.1097/JCP.0b013e31829a83f5 65

doi:10.1186/s13075-023-03043-5

results visible on light-medium brown skin: 1-3 months, dark brown skin: 3-6 months, very dark skin: 6-12 months & black skin: 18 months minimum and above

Rondanelli M, Riva A, Petrangolini G, Allegrini P, Giacosa A, Fazia T, Bernardinelli L, Gasparri C, Peroni G, Perna S (2021) Berberine phospholipid is an effective insulin sensitizer and improves metabolic and hormonal disorders in women with polycystic Ovary Syndrome: A one-group pretest-post-test explanatory study