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### How Oral Semaglutide Reaches the Bloodstream Oral semaglutide relies on SNAC to protect the peptide from acid degradation and facilitate transcellular transport across the gastric epithelium

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Additionally, by integrating material-specific properties with stimuli-responsive release mechanisms triggered by conditions like pH changes, glucose levels, or redox reactions, GLP-1R-targeted nanoplatforms become programmable delivery vehicles (Table 2)