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Critically, a detailed analysis found that the presence, titer (concentration), or neutralizing status of these ADAs had no clinically meaningful impact on the pharmacokinetics (i.e., drug clearance) or the efficacy (as measured by changes in HbA1c and body weight) of Tirzepatide

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For acute metabolic effects and rapid assessment: An 8-week cycle with a 4-week washout is the appropriate starting structure