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Patients can also consider filling the deflated areas with either their own fat or other products, including hyaluronic acid-based and human-derived fat products." Surgical options can help improve the appearance of the area and help reduce irritation and chaffing caused by excess skin

The result is fat oxidation without anabolic effects

GLP-1 medications work through several complementary mechanisms: Enhancing insulin secretion from pancreatic beta cells in a glucose-dependent manner, which helps lower blood sugar levels Suppressing glucagon release , thereby reducing hepatic glucose production Slowing gastric emptying , which prolongs satiety and reduces appetite Acting on appetite centres in the brain , leading to reduced caloric intake and weight loss Commonly prescribed GLP-1 receptor agonists available in the UK include semaglutide (Ozempic, Wegovy, Rybelsus [oral form]), dulaglutide (Trulicity), liraglutide (Victoza, Saxenda), and exenatide (Byetta, Bydureon)

Individual genetic sensitivity to each pathway varies significantly

That is why it is important to consider what treatments are the best fit for your goals

The Menopause Society identifies hormone therapy as the most effective treatment for vasomotor symptoms (VMS) in appropriate candidates