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Malonyl-CoA also plays a vital role in PUFA synthesis, where dietary linoleic acid undergoes sequential desaturation and elongation reactions catalyzed by fatty acid desaturase (FADS)2, ELOVL5 and FADS1, leading to the formation of AA (C20:4, -6), which can be further elongated by ELOVL2/4 to generate AdA (C22:4, -6) (76)
Its prolonged use is limited by the development of tachyphylaxis
When a microneedle patch is applied, it creates microscopic channels in the skin, allowing medicines or biological substances to pass through 15
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