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Finley EM

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NNMT (nicotinamide N-methyltransferase) is the enzyme 5-Amino-1MQ inhibits, and tissue expression varies significantly across organs: adipose tissue shows 812 higher NNMT activity than skeletal muscle, which is why subcutaneous injection near adipose depots produces localised effects rodent models couldn't predict

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Marx N, Husain M, Lehrke M, Verma S, Sattar N

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Furthermore, the change in the HbA1c value from baseline did not affect the result, suggesting that once-weekly exenatide reduced albuminuria independent of the glucose-lowering effect (Van Der Aart-Van Der Beek et al., 2020)

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Stopping medication temporarily is generally considered safer than continuing

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Role of the Adipocyte in Development of Type 2 Diabetes Rijeka: IntechOpen

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