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Safety, particularly regarding immunogenicity, constitutes another critical challenge

They also risk becoming malnourished and weak due to their bodies inability to absorb calories and nutrients from food

Pugliese NR, Paneni F, Mazzola M et al (2021) Impact of epicardial adipose tissue on cardiovascular haemodynamics, metabolic profile, and prognosis in heart failure

P1 is further cleaved by a viral protease into capsid subunit proteins VP0, VP1, and VP3, with VP0 undergoing autocleavage during virion maturation to yield VP2 and VP4 5,6,7

Jan 2021;114(Pt A):107608