Madecassoside & Asiaticoside: Soothe the skin and reduce irritation
In a 2023 review, inositol supplementation was described as an effective and safe treatment in PCOS, with outcomes comparable to metformin in some cases.5 L-Methylfolate (500mcg): Folate has been shown to positively affect glycemic, inflammatory, and oxidative stress markers in women with PCOS.7 It may also support fertility and reproductive outcomes, particularly when combined with other nutrients.67 Wholesome Story uses L-methylfolate (MTHF), the biologically active form of folate, which does not require conversion in the body and is often chosen in reproductive-health formulations.86 Vitamin D3 (1,000 IU): One additional consideration is dosing flexibility
Full 2026 regulatory status, Category 2 reclassification updates, compounding regulations, and published research
Creams and lotions These are more hydrating and often include additional ingredients such as hyaluronic acid, peptides, and antioxidants
Lienkamp K, Madkour AE, Musante A, Nelson CF, Nsslein K, Tew GN
Survival or death of neural cells in the penumbra correlates with the frequency of these transient ischaemic depolarisations