Other groups who may benefit include: Patients following gastric surgery (gastrectomy, bariatric procedures) where intrinsic factor production or absorption sites are compromised Individuals with malabsorption disorders such as Crohn's disease, coeliac disease, or chronic pancreatitis Strict vegans and vegetarians with dietary insufficiency, though oral supplementation is usually tried first Elderly patients with atrophic gastritis or reduced gastric acid production Patients on long-term metformin or proton pump inhibitors, which can impair B12 absorption [6] [8] Individuals with nitrous oxide exposure (recreational or medical), which can cause functional B12 deficiency Diagnosis typically involves serum B12 measurement, with levels below approximately 148 pmol/L (though thresholds vary between laboratories) generally indicating deficiency
The tradeoff is larger injection volumes at higher doses
NIH Office of Dietary Supplements Vitamin B12 Health Professional Fact Sheet: link MedlinePlus Cyanocobalamin injection: link Mayo Clinic Cyanocobalamin (intramuscular route): link IAPAM MIC Injections: link Fastic Do Vitamin B12, Lipo, and MIC Injections Actually Work for Weight Loss?: link FDA Using Fat-Dissolving Injections That Are Not FDA Approved Can Be Harmful: link Jacobson Cosmetic Surgery SlimShots (MIC/B12): link Eden B12 MIC Shots for Weight Loss: Cost & Reviews: link Journal of Clinical Endocrinology & Metabolism Inositol for PCOS: Systematic Review and Meta-analysis (2024): link
The peptide disperses through the digestive system before reaching musculoskeletal tissue, and the concentration arriving at the injury site through the oral route is a fraction of what an injection delivers directly
PMC 2648137
Patients interested in exploring how B12 deficiency treatment options compare including injections versus oral supplements can find detailed guidance tailored to individual needs
