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In addition, LEP increased the viability of HG-induced human umbilical vein endothelial cells, decreased ROS production, and reversed the inhibition of -glucosidase activity

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Th2 and Th17 cytokines promote inflammation and endometrial cell proliferation, while Tregs induce local immunosuppression by polarizing macrophages into pro-repair subtypes via soluble fibrinogen-like protein 2 (sFGL2) (23)

The rationale of indoleamine 2,3-dioxygenase inhibition for cancer therapy