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Glutathione is synthesized endogenously by the sequential action of glutamate-cysteine ligase and glutathione synthetase
2 In the UK, NAC is licensed for IV use in paracetamol poisoning, as eye drops in tear deficiency, and orally as a mucolytic in adults with respiratory conditions such as chronic obstructive pulmonary disease (COPD)
Rahman I, Kode A, Biswas SK: Assay for quantitative determination of glutathione and glutathione disulfide levels using enzymatic recycling method
Lipid aldehydic products like MDA and 4-HNE can enhance inflammation by stimulating pro-inflammatory genes and producing cytokines