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Nevertheless, due to the challenges of obtaining an ideal mixture of material and processes and achieving optimal ruminal escape and a high intestinal release of Met, a more efficient method was created to substitute the initial encapsulation method (Schwab and Ordway, 2003)

4,8,10 With several DPP-4 inhibitors in clinical development, their long-term safety profile as well as cardiovascular morbidity and mortality has become of significant interest