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The glutamine synthase is also present in the astrocytes in the brain for the removal of ammonia, as well as in the kidney and skeletal muscle

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Since tirzepatide already delays gastric emptying, high fat foods that amplify this effect may worsen digestive upset

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Besides the CREDENCE trial, other non-empagliflozin trials also failed to show significant changes.12,19 Trials of non-empagliflozin SGLT2 inhibitors investigating mortality endpoints are needed to fill in the evidence gap