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Kim J, Lee S G, Lee J, et al
While the mechanistic insights are encouraging, further clinical investigations are needed to isolate the direct analgesic effects of GLP-1R agonists from those mediated by weight loss
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For example, 100mcg twice daily for 20 days requires 4mg total
Notably, PFD could not increase the cell number of AEC2 in our experiment, also, FOXO4DRI could not improve the percentage of endothelial cells, which can be rescued by PFD