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More serious but rarer side effects include pancreatitis (uncertain risk increase), gallbladder disease (increased risk with rapid weight loss), hypoglycemia when combined with other diabetes medications, and injection site reactions

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4, 5, 6, 7 GIP is secreted from K cells in the proximal small bowel and binds to GIP receptors expressed by pancreatic islet cells, as well as to receptors in adipose tissue and the brain

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