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This stability profile distinguishes it from many peptide-based research compounds and has contributed to interest in its biochemical persistence, signaling activity, and pathway-specific effects in mechanistic investigations

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(33896531) Phenytoin accumulation, as well as an increased free fraction of phenytoin, may tend to cause phenytoin toxicity

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Reports of gene-expression changes affecting thousands of genes at certain doses and exposure times are unusual in the peptide literature, and the interpretation has been an area where the more enthusiastic readings (the compound has broad regulatory activity across many cellular processes) and the more cautious readings (broad gene-expression effects can reflect secondary consequences and may not all be specific or mechanism-based) coexist in the discourse