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DATA SYNTHESIS: Studies of antidote efficacy in humans are ethically and logistically difficult

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One observational study in pregnant women at high risk for preeclampsia found that those who were riboflavin deficient were 4.7 times more likely to develop preeclampsia than those who had adequate riboflavin nutritional status

It impacts the drugs effectiveness and higher bioavailability may lead to fewer side effects

The absorption barrier: in adults with impaired or reduced intrinsic factor, normal absorption drops significantly