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Metabolites such as lactate not only may play a crucial role in immune modulation but also may contribute to central sensitization by altering the synaptic microenvironment (146), thereby potentially establishing a direct link between peripheral metabolic dysfunction and central nervous system inflammation

Instead, doctors may lean towards recommending lifestyle adjustments or medications that have been scientifically proven to effectively treat medical conditions

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Properties and functions of adipose tissue macrophages in obesity

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