Antioxidant Depletion: In an ironnitrilotriacetic acid rat model of hemochromatosis, renal samples showed increases in reactive intermediates, accompanied by decreased availability of systems that protect against oxidation by iron, such as vitamin E levels, the glutathione system, thiol-specific antioxidants, and superoxide dismutase
When free radical production exceeds cellular scavenging, lipid peroxidation, for instance, can be brought on by an overabundance of hydroxyl radicals and peroxynitrite, which destroys cell membranes and lipoproteins (Pizzino et al., 2017)
Research materials should be handled according to appropriate laboratory standards
S14S17, Fig
Synaptic plasticity and dysconnection in schizophrenia
Not nearly enough for many