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Available at: Accessed: 05 March 2026) Thousands of participants were monitored for side effects, and among these participants: 3% of semaglutide users reported hair loss 1% of placebo users reported hair loss At first glance, this difference might suggest that semaglutide does increase the risk of hair loss

by mid-2025, spend had reached over $7 billion across the GLP-1 class

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In the SUSTAIN6 trial, semaglutide (a GLP-1RA) significantly increased diabetic retinopathy complications, including vitreous hemorrhage [2], while a recent retrospective cohort study of patients with type 2 diabetes showed that use of GLP-1RAs modestly increased the incident risk of diabetic retinopathy, although sight-threatening diabetic complications including blindness were somewhat lower in patients treated with GLP-1 RAs [5]

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